Genomic Profiling

genomic testing laboratory technician

A genomic profile is more than just a test. Our assays provide biomarker information with the hope of matching patients to approved targeted therapies, immunotherapies, and clinical trials — giving doctors and patients potentially powerful actionable insights for navigating cancer care.

QUICK GUIDE TO GENOMIC PROFILING

Review our Interactive Quick Guide to learn more about Genomic Profiling.

EVERY CANCER IS UNIQUE

Cancer occurs when the DNA in a human cell becomes damaged or mutates in such a way that the body is unable to identify the problem or repair it. These abnormal cells can grow out of control and form tumours or masses that invade healthy tissue and organs.

Traditionally, cancer has been categorized according to its location in the body, such as lung cancer, breast cancer, etc., and most patients with a particular tumour type are treated based on its categorization by location in the body.

Cancer researchers have identified specific genes that are related to cancer growth. As a result, cancer can now also be categorized by the underlying changes in DNA, or genomic alterations that drive the tumour’s growth.1

Targeted therapy is a type of cancer treatment designed to be specific to tumours that harbour the appropriate genomic alteration. Targeted therapy is a growing part of many cancer treatment regimens.2

Genomic testing or profiling identifies the underlying DNA alterations that may be driving the tumour’s growth.3 This information may help physicians understand which potential next steps are available for a patient based on their tumour’s unique genomic profile.

Comprehensive genomic profiling with FMI also looks at complex genomic signatures that most standard tests can't assess. The latest science indicates that these new kinds of biomarkers can help a physician better understand the potential role immunotherapies may play for any given patient's disease.

FIND OUT HOW GENOMIC PROFILING A TUMOUR CAN HELP YOU

COMPREHENSIVE GENOMIC PROFILING CAN HELP TAILOR YOUR NEXT STEP

Even when two people have tumours in the same part of their body, their tumours are most likely different at a basic, molecular level – that is, there may be different genomic alterations causing each person’s cancer to grow.1

Comprehensive Genomic Profiling cancer tests such as FoundationOne® and FoundationOne® Heme may provide the information your physician needs in one single test to help guide or tailor your next step. You and your doctor can potentially use the results from FoundationOne® or FoundationOne® Heme to better understand your disease and may be able to identify approved targeted therapies, immunotherapies or therapies under development in clinical trials.

Talk to your doctor about Comprehensive Genomic Profiling and learn how you may benefit from creating a tailored plan.

FOUNDATION TESTS AVAILABLE IN CANADA

Our Diagnostic Portfolio

  • FOUNDATIONONE®
  • CONDITION

    NSCLC, CRC, Melanoma, and other solid tumours
  • SAMPLE TYPE

    Formalin-fixed, Paraffin-embedded (FFPE) tissue
  • GENOMIC SIGNATURES

    Microsatellite Instability (MSI)Tumour Mutational Burden (TMB)
  • Details →
Overview

HOW DOES IT WORK?

  • foundation medicine physician order

    Step 1

    Physician orders the FoundationOne® test

  • pathologist prepares tumour sample

    Step 2

    Pathologist prepares tumour sample and ships to Foundation Medicine

  • Step 3

    Foundation Medicine receives the tumour sample

  • DNA extraction from tumour

    Step 4

    DNA is extracted from the tumour sample

  • Genomic Analysis of Tumour DNA

    Step 5

    Foundation Medicine determines the unique genomic code of the tumour

  • Step 6

    A team of genomic experts analyze the data and determine potential next steps for each patient based on the genomic alterations identified

Results & Reporting

Test results are provided directly to physicians in a report that highlights the genomic alterations in a patient’s cancer and includes information to help inform next steps. Everything in the report is supported by up-to-date clinical findings and scientific research.

Are you a patient ready to talk to your doctor about genomic profiling?

Foundation Medicine Tests are ordered by your healthcare provider. Our Ask Your Doctor pamphlet has all the information you and your doctor need to discuss Foundation Medicine testing.
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